Dtx3l (NM_001013371) Mouse Recombinant Protein-蛋白质/抗原/多肽-试剂-生物在线
安诺伦(北京)生物科技有限公司
Dtx3l (NM_001013371) Mouse Recombinant Protein

Dtx3l (NM_001013371) Mouse Recombinant Protein

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产品名称: Dtx3l (NM_001013371) Mouse Recombinant Protein

英文名称: Dtx3l (NM_001013371) Mouse Recombinant Protein

产品编号: PM45273M5

产品价格: 0

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围: null

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产品概述:Purified recombinant protein of Mouse deltex 3-like, E3 ubiquitin ligase (Dtx3l), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM39309V], encoding Mouse full-length Dtx3l.

表达系统:HEK293T

种属:Mouse

标签类型:C-MYC/DDK

分子量:76.6 kDa

通用名:Dtx3l

总结:E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes.[UniProtKB/Swiss-Prot Function]

形式:Liquid

浓度:>50 ug/mL as determined by microplate BCA method

纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

别名:AU042200; BC023741